I've seen systems in a few cities that work almost like a subway system. Major arteries like Poplar and, lets say Perkins (or whatever) are serviced in straight lines, with buses arriving every 5 to 10 minutes. If you need to change directions, you transfer to a line running perpendicular which has buses every 5 to 10 minutes. For me, in midtown, if I wanted to go to the university, I would walk the 2 blocks to McLean, wait no more than 5 minutes, take a bus down to Central, wait no more than 5 minutes and take a bus straight down Central to the university. A route down the Airways/East Parkway line would take you to the airport.
With all the buses going in straight lines on major streets, running every few minutes, getting anywhere in a predictable amount of time would be a much more likely (and attractive) possiblity.
Bemused