Memphis built an early double-digit lead and the Sixers never threatened as the Grizzlies went on to a 118-102 victory on Wednesday night.
Mike Miller scored 30 points and Rudy Gay added 23 to lead Memphis.
The Grizzlies, who led by as many as 25 in the first half, snapped a three-game losing streak as seven players scored in double figures. Lawrence Roberts and Chucky Atkins scored 13 apiece for Memphis, while Pau Gasol had 12 points and 12 rebounds. The Grizzlies' margin of victory was their largest in 10 wins this season.