The Pistons, who have won four straight and 11 of 13, got 14 points each from Chauncey Billups and Richard Hamilton. Rookie Arron Afflalo added a career-best 12.
Detroit's more-heralded rookie, Rodney Stuckey , made his NBA debut in the fourth quarter. Stuckey, the 15th pick in June's draft, missed the first 25 games with a broken hand.
Rudy Gay led the Grizzlies with 18 points, but added to Memphis' offensive problems by missing a pair of wide-open dunks. Pau Gasol returned to the Memphis lineup after missing four games with a toe injury. He finished with 10 points and 10 rebounds in 31 minutes, but went 4-for-14 from the floor as Memphis shot 33.8 percent.
The Pistons led 42-38 at the half, missing seven of eight 3-point attempts. Hamilton had 12 points in the half.
Rasheed Wallace 's 3-pointer early in the third kicked off an 8-2 run that gave the Pistons a 52-45 lead, and they expanded the margin to 68-54 at quarter's end.
The Grizzlies had seven turnovers in the third and six field goals. Gay didn't help when he missed his second dunk, then was called for offensive goaltending while trying to hang on the rim and catch the bounce.
Detroit pulled away in the fourth while both teams emptied their benches.